Brain metastases in patients with renal cell carcinoma: prognosis and treatment

Journal Article · Thu Mar 01 04:00:00 EST 1984 · J Clin Oncol; (United States)

OSTI ID:6833211

Decker, D A; Decker, V L; Herskovic, A; Cummings, G D

Thirty-four patients with renal cell carcinoma and brain metastases were reviewed to define important prognostic factors and treatment results. The following covariates were analyzed to determine their influence on survival: disease-free interval, serum calcium, number of central nervous system (CNS) metastases, weight loss, performance score, age, radiation therapy, surgery, and surgery plus radiation. The mean survival for all patients was 7.0 months (range, seven days to 32 months). The patients with a good performance score of 0-2 survived significantly longer (mean survival, 10.2 months) than those with a poor performance score of 3-4 (mean survival, 2.8 months; p . 0.0019). Surgery was associated with significantly improved survival (mean survival, 13.8 months versus mean survival, 4.2 months; p . 0.014). However, all the surgical patients were from the good performance score group, suggesting patient selection. Radiation was associated with an improved mean survival of 8.6 months versus 3.2 months. Performance score is a significant prognostic factor. Furthermore, the data support treatment with radiation therapy for patients with multiple CNS metastases and surgery followed by postoperative radiation therapy for patients with single CNS metastases.

• Research Organization: Division of Oncology, Wayne State University and Harper-Grace Hospital, Detroit, MI
• OSTI ID: 6833211
• Journal Information: J Clin Oncol; (United States), Journal Name: J Clin Oncol; (United States) Vol. 2:3
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
BRAIN
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DISEASES
KIDNEYS
MEDICINE
METASTASES
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
RADIOTHERAPY
SURGERY
SURVIVAL TIME
THERAPY