Effect of restraint and copper deficiency on blood pressure and mortality of adult rats

Journal Article · Wed Feb 01 00:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:6832635

Klevay, L M; Halas, E S ^[1]

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1. Univ. of North Dakota, Grand Forks (USA)

The etiology of most hypertension is unknown; stress is thought to elevate blood pressure. Male, weanling Sprague-Dawley rats were fed a purified diet plus a drinking solution containing 10{mu}g Zn and 2{mu}g Cu/ml (acetate sulfate, respectively). Systolic blood pressure was measured without anesthesia. After being matched by mean weight (280g) and blood pressure into 4 groups of 15, groups 1 and 2 received a drinking solution without copper. After 24 days rats in groups 2 and 4 were restrained for 45 min. daily (A.M.) for 23 days in a small plastic cage (19{times}6{times}6 cm). Final pressures were affected both by stress and dietary Cu: group 1, 119; group 2, 131; group 3, 114; group 4, 123 mm Hg. One rat in each of groups 1, 3, 4 and 10 rats in group 2, died. Among these latter hemorrhage was prominent, blood being found in bladder (2), gut (2), peritoneum (2) and scrotum (1). Copper deficiency decreased cooper in both adrenal gland and liver by 58% and in heart by 29% restraint was without effect. Cardiac sodium was increased 6% only by deficiency. Results confirm the hypertensive effect of copper deficiency in adult rats and reveal that the stress of restraint increases blood pressure. Copper deficiency plus stress is harmful.

• OSTI ID: 6832635
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Vol. 3:4; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER
BIOLOGICAL EFFECTS
HYPERTENSION
ETIOLOGY
BIOLOGICAL STRESS
MORTALITY
NUTRITIONAL DEFICIENCY
RATS
ANIMALS
CARDIOVASCULAR DISEASES
DISEASES
ELEMENTS
MAMMALS
METALS
RODENTS
SYMPTOMS
TRANSITION ELEMENTS
VASCULAR DISEASES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology