Primary tumor control after radiotherapy for carcinoma of the bronchus

Journal Article · Sun Apr 01 04:00:00 EST 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90029-4· OSTI ID:6831957

Saunders, M I; Bennett, M H; Dische, S; Anderson, P J

The primary tumor control and the appearance of distant metastasis was observed closely in 62 patients entered into a randomized controlled trial of the radiosensitizing drug, misonidazole, in carcinoma of the bronchus. Sixty-one of the 62 patients are now dead; an autopsy examination was carried out in 42 (69%). Although survival was comparable to that observed in similar studies, tumor persisted or recurred at the primary site in 95% (58/61) while 39% (24/61) showed no evidence for distant metastasis. In these patients, improvement in the primary tumor control would be important in extending survival. Complications of this treatment are discussed.

• Research Organization: Mount Vernon Hospital, Northwood, England
• OSTI ID: 6831957
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:4; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCESSES
ANTINEOPLASTIC DRUGS
AUTOPSY
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRONCHI
CARCINOMAS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
FIBROSIS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
LUNGS
MEDICINE
METASTASES
MISONIDAZOLE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIZERS
RADIOTHERAPY
RESPIRATORY SYSTEM
SIDE EFFECTS
THERAPY