Methemoglobin-producing effect and its role in the mechanism of action of some radioprotective agents in the benzo-2,1,3-thiadiazole class. [Mice, dogs, gamma radiation]
A study was made of some derivatives of benzo-2,1,3-thiadiazole with regard to their capacity to form methemoglobin in blood. It was demonstrated that, 30 min after intraperitoneal administration of radioprotective doses of such agents to mice, the blood methemoglobin level does not exceed 5 percent. With administration to mice of 4-aminobenzo-2,1,3-thiadiazole in a toxic dose 14 percent methemoglobin is produced in blood. In dogs, almost 50 percent methemoglobin is formed in blood after oral intake of 4-aminobenzo-2,1,3-thiadiazole; this is a level that can provide for the radioprotective action of this compound. Using agents that prevent oxidation of hemoglobin to methemoglobin (2-methoxy-9-phenazine sulfate and isonicotinic acid hydrazide), it was demonstrated that the methemoglobin formed in mouse blood does not play a leading role in manifestation of the radioprotective action and toxic properties of 4-aminobenzo-2,1,3-thiadiazole.
- OSTI ID:
- 6830061
- Journal Information:
- Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 17:6; ISSN RADBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AZOLES
BENZOTHIAZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOSYNTHESIS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GLOBIN
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
MAMMALS
METHEMOGLOBIN
MICE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SYNTHESIS
THIAZOLES
VERTEBRATES