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Assessment of methods and results of reproductive occupational epidemiology: spontaneous abortions and malformations in the offspring of working women

Journal Article · · Prog. Clin. Biol. Res.; (United States)
; ; ;
Epidemiological studies relating occupational exposures of working women to spontaneous abortions and malformation are reviewed and some methodological considerations are presented. The reproductive epidemiology is less developed than epidemiology in general and seems to involve some specific problems. The exposures may be reported differently by the women depending on the outcome of the pregnancy; thus confirmation of exposure from an independent data source would be an asset. The types of occupational exposures of the women, suggested to carry a risk of spontaneous abortions, include anesthetic agents, laboratory work, copper smelting, soldering, and chemical sterilization using ethylene oxide and glutaraldehyde. Maternal employment in laboratories and exposure to solvents has been linked to a risk of congenital malformations in the offspring in five studies. Data on the teratogenic effects of anesthetic gases has been conflicting. In one study, employment in copper smelting was associated with malformations in the offspring.
Research Organization:
Institute of Occupational Health, Haartmaninkatu, Helsinki, Finland
OSTI ID:
6829619
Journal Information:
Prog. Clin. Biol. Res.; (United States), Journal Name: Prog. Clin. Biol. Res.; (United States) Vol. 117; ISSN PCBRD
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABORTION
ALDEHYDES
ANESTHETICS
ANIMALS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONGENITAL MALFORMATIONS
COPPER
DRUGS
ELEMENTS
EPIDEMIOLOGY
EPOXIDES
FABRICATION
FEMALES
HAZARDS
HEALTH HAZARDS
HETEROCYCLIC OXYGEN COMPOUNDS
JOINING
MALFORMATIONS
MAMMALS
MAN
METALS
OCCUPATIONS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PERSONNEL
PREGNANCY
PRIMATES
SMELTING
SOLDERING
SOLVENTS
STERILIZATION
TRANSITION ELEMENTS
VERTEBRATES
WELDING
WOMEN