Identification of a second pseudoautosomal region near the Xq and Yq telomeres

Journal Article · Fri Dec 11 04:00:00 EST 1992 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.1465614· OSTI ID:6827158

Freije, D; Helms, C; Watson, M S; Donis-Keller, H ^[1]

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1. Washington Univ. School of Medicine, St. Louis, MO (United States)

The telomeres of Xq and Yq have been observed to associate during meiosis, and in rare cases a short synaptonemal complex is present. Molecular cloning of loci from Xqter and Yqter has revealed that their sequence homology extends over 400 kilobases, which suggests the possibility of genetic exchange. This hypothesis was tested by the development of two highly informative microsatellite markers from yeast artificial chromosome clones that carried Xqter sequences and the following of their inheritance in a set of reference pedigrees from the Centre d'Etude du Polymorphisme Humain in Paris, France. From a total of 195 informative male meioses, four recombination events between these loci were observed. In three cases, paternal X alleles were inherited by male offspring, and in one case a female offspring inherited her father's Y allele. These data support the existence of genetic exchange at Xq-Yq, which defines a second pseudoautosomal region between the sex chromosomes.

• OSTI ID: 6827158
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 258:5089; ISSN SCIEAS; ISSN 0036-8075
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MARKERS
CELL DIVISION
CHROMOSOMES
CLONING
DNA
EUMYCOTA
FUNGI
GENE RECOMBINATION
GENETIC MAPPING
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
HUMAN Y CHROMOSOME
MAPPING
MEIOSIS
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PLANTS
X CHROMOSOME
Y CHROMOSOME
YEASTS