Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · Am. J. Surg. Pathol.; (United States)

DOI:https://doi.org/10.1097/00000478-198807000-00007· OSTI ID:6823533

Weiss, S W; Bratthauer, G L; Morris, P A

A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein.

• Research Organization: Armed Forces Institute of Pathology, Washington, DC (USA)
• OSTI ID: 6823533
• Journal Information: Am. J. Surg. Pathol.; (United States), Journal Name: Am. J. Surg. Pathol.; (United States) Vol. 12:7; ISSN AJSPD
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBODIES
BIOSYNTHESIS
BODY
CARCINOMAS
DISEASES
FEMALE GENITALS
IMMUNE REACTIONS
KERATIN
MEDICINE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SCLEROPROTEINS
SIDE EFFECTS
SKELETON
SYNTHESIS
THERAPY
UTERUS