Exposures of older adults with chronic respiratory illness to nitrogen dioxide. A combined laboratory and field study

Journal Article · Tue Dec 01 04:00:00 EST 1992 · American Review of Respiratory Disease; (United States)

DOI:https://doi.org/10.1164/ajrccm/146.6.1480· OSTI ID:6819776

Hackney, J D; Linn, W S; Avol, E L; Shamoo, D A; Anderson, K R; Solomon, J C; Little, D E; Peng, R C ^[1]

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1. Univ. of Southern California School of Medicine, Downey (United States)

We combined field and laboratory experimentation to evaluate the effects of nitrogen dioxide in a panel of Los Angeles area residents with chronic respiratory illness, 15 men and 11 women aged 47 to 69. All had heavy smoking history, chronic symptoms, and low FEV1; some also had low FVC. During the fall-winter high-NO2 season, they monitored themselves for 2-wk periods using spirometers in the home, passive NO2 sampling badges, and diaries to record time and activity patterns and clinical status. In the middle of each self-monitoring week they were exposed in a chamber, once to clean air and once to 0.3 ppm NO2. Chamber exposures were double blind, lasted 4 h, and included four 7-min exercise sessions with average ventilation rates near 25 L/min. Symptom reports and hourly forced expiratory function tests showed no statistically significant differences between clean air and NO2 chamber exposures, although peak flow showed a approximately 3% loss with NO2 relative to clean air during the first 2 h of exposure only (p = 0.056). No significant overall differences were found between field self-measurements and measurements of lung function in the chamber or between field measurements in clean air and NO2 exposure weeks. Field data showed that group average lung function and symptom levels were worse in the morning than later in the day (p < 0.005) but otherwise were stable over 2 wk. Even though most subjects smoked and stayed indoors 80 to 90% of the time, personal NO2 exposures correlated significantly with outdoor NO2 concentrations as reported by local monitoring stations.

• OSTI ID: 6819776
• Journal Information: American Review of Respiratory Disease; (United States), Journal Name: American Review of Respiratory Disease; (United States) Vol. 146:6; ISSN ARDSBL; ISSN 0003-0805
• Country of Publication: United States
• Language: English

Related Subjects

550500 -- Metabolism
560300* -- Chemicals Metabolism &amp; Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
AIR POLLUTION
CALIFORNIA
CHALCOGENIDES
CLEARANCE
DEVELOPED COUNTRIES
DISEASES
ENVIRONMENTAL EXPOSURE
EXCRETION
LOS ANGELES
LUNG CLEARANCE
MONITORING
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
NORTH AMERICA
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATION
RESPIRATORY SYSTEM DISEASES
URBAN AREAS
USA