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Increased /sup 3/H-spiperone binding sites in mesolimbic area related to methamphetamine-induced behavioral hypersensitivity

Journal Article · · Biol. Psychiatry; (United States)
OSTI ID:6817060
; ;
The specific /sup 3/H-spiperone binding to membrane homogenates of the striatum, mesolimbic area, and frontal cortex was examined in two groups of rats pretreated once daily with saline or 4 mg/kg of methamphetamine (MAP) for 14 days. At 7 days following cessation of chronic pretreatment, all rats received an injection of 4 mg/kg of MAP and were decapitated 1 hr after the injection. In the chronic saline-pretreatment group, the single administration of MAP induced significant changes in the number (Bmax) of specific /sup 3/H-spiperone binding sites (a decrease in the striatum and an increase in the mesolimbic area and frontal cortex), but no significant changes in the affinity (KD) in any brain area. The chronic MAP pretreatment markedly augmented the changes in Bmax in the striatum and mesolimbic area. The increase in specific /sup 3/H-spiperone binding sites in the mesolimbic area is discussed in relation to MAP-induced behavioral hypersensitivity.
Research Organization:
Department of Neuropsychiatry, Okayama University Medical School, Japan
OSTI ID:
6817060
Journal Information:
Biol. Psychiatry; (United States), Journal Name: Biol. Psychiatry; (United States) Vol. 17:2; ISSN BIPCB
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BENZEDRINE
BINDING ENERGY
BIOLOGICAL EFFECTS
BODY
BRAIN
CELL CONSTITUENTS
CELL MEMBRANES
CENTRAL NERVOUS SYSTEM
CHRONIC EXPOSURE
COMPARATIVE EVALUATIONS
DRUGS
ENERGY
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
METABOLISM
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
RATS
RECEPTORS
RODENTS
SENSITIVITY
SYMPATHOMIMETICS
TRITIUM COMPOUNDS
VERTEBRATES