Gamma-emitting receptor-binding 3-quinuclidinyl gycolates; methods of preparation thereof and imaging and assay methods utilizing same

Patent · Tue Feb 14 04:00:00 EST 1984

OSTI ID:6816849

Eckelman, W C; Gibson, R E; Reba, R C; Rzeszotarski, W J

Compounds of the formula: ((1-R1-QUI NU CL I DIN-3-YL(+))-OOC-C (-R) (-OH)-), X-Benzene Z(-) wherein R is aryl, alkyl, cycloalkyl, phenyl, cyclopentyl, cyclohexyl, a ligand containing Tc-99m in chelated form or a ligand capable of chelating Tc-99m; R/sub 1/ is H or lower alkyl; X is in the ortho-, meta or para- position, and is selected from the group consisting of /sup 125/I, /sup 123/I, /sup 127/I, I, /sup 18/F, /sup 75/Br, /sup 77/Br, NH/sub 2/, and 1-(N=N-), R/sub 2/-Piperidine wherein R/sub 2/ is in the 2,3, or 4 position and is selected from the group consisting of H and lower alkyl, provided that when R is a ligand capable of chelating Tc-99m o containing Tc-99m in chelated form, X is not a radioisotope and may also be H or lower alkyl; Z/theta/ is an anion; or the free amine thereof; and denotes an asymmertric carbon atom.

• Assignee: Research Corporation
• Patent Number(s): US 4431627
• OSTI ID: 6816849
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400700 -- Radiochemistry & Nuclear Chemistry
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BROMINE 75
BROMINE 77
BROMINE ISOTOPES
CHELATING AGENTS
CHEMICAL COMPOSITION
CHEMICAL PREPARATION
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FLUORINE 18
FLUORINE ISOTOPES
GAMMA SOURCES
HALOGENS
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE
IODINE 123
IODINE 125
IODINE 127
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LABELLING
LIGANDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIPERIDINES
PYRIDINES
RADIATION SOURCES
RADIOASSAY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RECEPTORS
STABLE ISOTOPES
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES