Comparative metabolism of 2-nitropropane in rats and chimpanzees

Journal Article · Sat Jan 01 00:00:00 EST 1983 · Chemosphere; (United States)

DOI:https://doi.org/10.1016/0045-6535(83)90166-2· OSTI ID:6815274

Mueller, W F; Coulston, F; Korte, F

To obtain more information about the metabolic fate of 2-nitropropane (2-NP) in rats and to study the relevance of the findings for man, the authors investigated the metabolism of 2-NP in rats and chimpanzees. The results of this study show that 2-NP is eliminated largely by exhalation, while excretion in urine and feces are only minor pathways. Carbon dioxide, acetone and isopropanol are the major metabolites. Preliminary chromatographic results suggest different conjugates formed by rats and chimpanzees. 2-NP has little potential for accumulation; the lipid tissues, which can absorb it to considerable concentrations, are rapidly depleted.

• Research Organization: Gesellschaft fuer Strahlen und Umweltforschungh mbH, Muenchen, West Germany
• OSTI ID: 6815274
• Journal Information: Chemosphere; (United States), Vol. 12:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
CARBON 14 COMPOUNDS
METABOLISM
NITRO COMPOUNDS
BLOOD PLASMA
COMPARATIVE EVALUATIONS
EXCRETION
EXHALATION
METABOLITES
PRIMATES
RATS
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY FLUIDS
CLEARANCE
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques