Interspecies toxicity correlations of rat, mouse and Photobacterium phosphoreum

Journal Article · Sat Oct 01 00:00:00 EDT 1994 · Environmental Toxicology and Chemistry; (United States)

DOI:https://doi.org/10.1897/1552-8618(1994)13[1599:ITCORM]2.0.CO;2· OSTI ID:6808931

Kaiser, K L.E.; McKinnon, M B ^[1]; Fort, F L ^[2]

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1. National Water Research Inst., Burlington, Ontario (Canada)
2. Abbott Labs., Abbott Park, IL (United States)

This study investigates quantitatively the interspecies relationships of the acute toxicity of 684 organic chemicals to the rate, the mouse, and the luminescent marine bacterium Photobacterium phosphoreum, commonly known as the Microtox[reg sign] test. The results indicate significant relationships between the Microtox EC50 and rat and mouse LD50 values. The goodness of fit increases strongly from the oral to the intraperitoneal to the intravenous route of administration for each of the mouse and rat. Standard errors of the estimated rat values range from 0.52 to 0.72 log units of toxicity (after and before outlier removal, respectively) over a toxicity range of 4.6 (intraperitoneal) to 5.0 (oral) log units (mmol/kg body weight) of toxicity. For each of the three routes of administration, rat and mouse data are also highly correlated. This allows the computation of rat toxicities from mouse data and vice versa with standard errors of the estimates of 0.28 (intraperitoneal) to 0.30 (oral) log units.

• OSTI ID: 6808931
• Journal Information: Environmental Toxicology and Chemistry; (United States), Vol. 13:10; ISSN 0730-7268
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MICE
SENSITIVITY
ORGANIC COMPOUNDS
TOXICITY
PHOTOSYNTHETIC BACTERIA
RATS
BIOASSAY
DATA COVARIANCES
GENETIC VARIABILITY
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
ORAL ADMINISTRATION
ANIMALS
BACTERIA
BIOLOGICAL VARIABILITY
INJECTION
INTAKE
MAMMALS
MICROORGANISMS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology