Neutron scattering studies of the H2a-H2b and (H3-H4)/sub 2/ histone complexes
Conference
·
OSTI ID:6808243
Neutron scattering experiments have shown that both the (H3-H4)/sub 2/ and H2a-H2b histone complexes are quite asymmetric in solution. The (H3-H4)/sub 2/ tetramer is an oblate or flattened structure, with a radius of gyration almost as large as that of the core octamer. If the tetramer is primarily globular, it must have an axial ratio of about 1:5. It is more likely, however, that this asymmetry results in part from N-terminal arms that extend outward approximately within the major plane of the particle. If this is the case, less asymmetric models for the globular part of the tetramer, including a dislocated disk, can be made consistent with the scattering data. The H2a-H2b dimer, on the other hand, is an elongated structure. 48 references, 12 figures, 1 table.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6808243
- Report Number(s):
- BNL-34674; CONF-8206240-5; ON: DE84012173
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400101 -- Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALGAE
CHROMATIN
COHERENT SCATTERING
DEUTERIDES
DEUTERIUM COMPOUNDS
DIFFRACTION
EUGLENA
HISTONES
HYDROGEN COMPOUNDS
HYDROGEN DEUTERIDE
MAGNETIC RESONANCE
MASTIGOPHORA
MATHEMATICAL MODELS
MICROORGANISMS
MOLECULAR MODELS
NEUTRON DIFFRACTION
NUCLEAR MAGNETIC RESONANCE
NUCLEOSOMES
ORGANIC COMPOUNDS
PLANTS
PROTEINS
RESONANCE
SCATTERING
UNICELLULAR ALGAE
400101 -- Activation
Nuclear Reaction
Radiometric & Radiochemical Procedures
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
ALGAE
CHROMATIN
COHERENT SCATTERING
DEUTERIDES
DEUTERIUM COMPOUNDS
DIFFRACTION
EUGLENA
HISTONES
HYDROGEN COMPOUNDS
HYDROGEN DEUTERIDE
MAGNETIC RESONANCE
MASTIGOPHORA
MATHEMATICAL MODELS
MICROORGANISMS
MOLECULAR MODELS
NEUTRON DIFFRACTION
NUCLEAR MAGNETIC RESONANCE
NUCLEOSOMES
ORGANIC COMPOUNDS
PLANTS
PROTEINS
RESONANCE
SCATTERING
UNICELLULAR ALGAE