Pharmacokinetics of (/sup 14/C)teicoplanin in male rats after single intravenous dose

Journal Article · Sat Nov 01 04:00:00 EST 1986 · Antimicrob. Agents Chemother.; (United States)

DOI:https://doi.org/10.1128/AAC.30.5.733· OSTI ID:6802750

Bernareggi, A; Cavenaghi, L; Assandri, A

The pharmacokinetic profile of (/sup 14/C)teicoplanin was studied in male Sprague-Dawley rats given a single 10,000-U/kg intravenous dose. The disposition of the antimicrobial activity in the body was estimated by a three-compartment open model. Plasma concentration data were fitted to a three-exponent equation. The profile of total /sup 14/C in plasma was similar to that of the microbiological activity. The cumulative recovery of total /sup 14/C 5 days after drug administration averaged 76.3% of the administered dose in the urine and 8.7% in the feces. The residual dose remaining in the animal carcasses was 11.1%. Teicoplanin was widely distributed in the body. In almost all organs, the maximum concentration of (/sup 14/C)teicoplanin was already reached at the first time of killing, which was 0.25 h after the administration of drug. The liver, kidneys, skin, and fat contained most of the residual dose found in the animal carcasses 120 h after administration and behaved as a deep compartment with the adrenal glands and spleen.

• Research Organization: Lepetit Research Center, Gruppo Lepetit S.p.A., Milan, Italy
• OSTI ID: 6802750
• Journal Information: Antimicrob. Agents Chemother.; (United States), Journal Name: Antimicrob. Agents Chemother.; (United States) Vol. 5; ISSN AMACC
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADSORPTION
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
DISTRIBUTION
DRUGS
FECES
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
RATS
RODENTS
SORPTION
TISSUE DISTRIBUTION
TRACER TECHNIQUES
URINE
VERTEBRATES
WASTES