Assays of thyroid-stimulating antibody

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Methods Enzymol.; (United States)

DOI:https://doi.org/10.1016/0076-6879(85)09123-6· OSTI ID:6801732

McKenzie, J M; Zakarija, M

A comparison is presented of the two major assay methods of thyroid-stimulating antibody (TSAb) of Graves' disease. The basic procedures involve: (1) some index of thyroid stimulation, usually in vitro, using TSAb to indicate its activity; and (2) indirect recognition by assessment of the inhibition of binding of radioiodinated thyrotropin (TSH) to a preparation of its receptor, i.e., TSH-binding inhibition or TBI. There is potential for misinterpretation of data acquired by testing patients' sera by one or the other basic procedure.

• OSTI ID: 6801732
• Journal Information: Methods Enzymol.; (United States), Vol. 109
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTIBODIES
RADIOIMMUNOASSAY
RADIORECEPTOR ASSAY
THYROID
BIOCHEMICAL REACTION KINETICS
COMPARATIVE EVALUATIONS
ENDOCRINE DISEASES
EXPERIMENTAL DATA
IMMUNOGLOBULINS
IODINE 125
LABELLED COMPOUNDS
RECEPTORS
STIMULATION
BETA DECAY RADIOISOTOPES
BODY
DATA
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
GLOBULINS
IMMUNOASSAY
IMMUNOLOGY
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MEMBRANE PROTEINS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
REACTION KINETICS
TRACER TECHNIQUES
550201* - Biochemistry- Tracer Techniques