Cardiovascular malformations and organic solvent exposure during pregnancy in Finland

Journal Article · Fri Jan 01 04:00:00 EST 1988 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700140102· OSTI ID:6800054

Tikkanen, J

In order to investigate the possible association between cardiovascular malformations and maternal exposure to organic solvents during the first trimester of pregnancy, 569 cases and 1,052 controls were retrospectively studied. The cases represented all infants with diagnosed cardiovascular malformations born in Finland in 1982-1984, and the controls were randomly selected from all normal births in the country during the same period. All mothers were interviewed approximately 3 months after delivery by a midwife using a structured questionnaire. Exposures to organic solvents at work during the first trimester of pregnancy were slightly more prevalent among the mothers of affected infants (10.4%) than among those of controls (7.8%). Logistic regression analysis of exposure to organic solvents showed an adjusted relative odds ratio of 1.3 (95% confidence interval, 0.8-2.2). In the analysis of ventricular septal defect, exposure to organic solvents showed an adjusted relative odds ratio of 1.5 (95% confidence interval, 1.0-3.7).

• Research Organization: National Public Health Institute, Helsinki (Finland)
• OSTI ID: 6800054
• Journal Information: Am. J. Ind. Med.; (United States), Journal Name: Am. J. Ind. Med.; (United States) Vol. 14:1; ISSN AJIMD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
CARDIOVASCULAR DISEASES
CHILDREN
CONGENITAL MALFORMATIONS
DISEASES
EUROPE
FINLAND
INFANTS
MALFORMATIONS
MATHEMATICS
OCCUPATIONAL EXPOSURE
ORGANIC SOLVENTS
PATHOLOGICAL CHANGES
PREGNANCY
REGRESSION ANALYSIS
SCANDINAVIA
SOLVENTS
STATISTICS
TERATOGENESIS
TOXICITY
WESTERN EUROPE