Noninvasive xenon-133 measurements of cerebral blood flow using stationary detectors compared with dynamic emission tomography

Journal Article · Mon Dec 01 04:00:00 EST 1986 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1986.130· OSTI ID:6796502

Schroeder, T; Vorstrup, S; Lassen, N A; Engell, H C

Repeated bedside measurements of CBF have been made possible by the recent development of a mobile unit with 10 stationary detectors using the intravenous xenon-133 method. To evaluate this technique, comparative CBF studies at rest and following the application of a cerebral vasodilatory stimulus (acetazolamide, 1 g i.v.) were performed with the mobile equipment and with xenon-133 single-photon emission inhalation tomography in patients with cerebrovascular disease. The CBF level and the flow response to acetazolamide as determined with the two methods were well correlated, although at low flow levels the stationary detectors yielded somewhat lower CBF values than did emission tomography. Considering the side-to-side asymmetry, an excellent correlation was obtained. Using the initial slope index, the stationary detectors revealed quantitatively 83% of the interhemispheric asymmetry and 63% of the asymmetry in the middle cerebral artery territory shown with the tomograph. As illustrated by a case history, the nontomographic CBF unit used in this study may provide reliable and useful information in patients with occlusive cerebrovascular disease by performing repeated CBF studies and challenging the cerebral circulation with acetazolamide.

• Research Organization: Rigshospitalet, Copenhagen, Denmark
• OSTI ID: 6796502
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Journal Name: J. Cereb. Blood Flow Metab.; (United States) Vol. 6; ISSN JCBMD
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMIDES
BLOOD CIRCULATION
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STABLE ISOTOPES
TOMOGRAPHY
VASCULAR DISEASES
XENON 132
XENON ISOTOPES