Comparative methods for quantifying total left ventricular infarct size in-vivo by single photon emission computerized tomography (SPECT)

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6794775

Prigent, F; Maddahi, J; Garcia, E; Resser, K; Berman, D

To assess the validity of SPECT for measuring the total left ventricular (LV) infarct size (IS), the authors compared 4 different methods (Mth) in 10 dogs with acute 8-hr closed chest coronary occlusion (LAD in 7 and LCX in 3). Ten min after 2 mCi of IV Tl-201, 30 30-sec projections were obtained over 180/sup 0/. After sacrifice, hearts were sliced and pathologic LV IS was determined by TTC staining. On each tomogram, SPECT IS was defined as % of the maximum count circumferential profile (CP) falling below normal (nl) limits which were derived from 6 nl dogs. SPECT LV IS was determined by adding % IS on each slice before (Mth number1) and after (Mth 2- 4) correction to account for differing myocardial slice masses. Correction was accomplished by multiplying slice IS by a weighting factor derived from an observed relationship between slice depth and its actual weight (Mth number2), its SPECT surface area (Mth number3), or its diameter x maximal count (Mth number4), a method independent of slice edge detection.

• Research Organization: Cedars-Sinai Medical Center, Los Angeles, CA
• OSTI ID: 6794775
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
CORRELATION FUNCTIONS
DETECTION
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
FUNCTIONS
HEART
MAMMALS
MATHEMATICAL MODELS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
ORGANS
PATHOLOGY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TESTING
TOMOGRAPHY
VALIDATION
VERTEBRATES