TPA induces cytoplasmic alkalinization in human monoblastic U-937 cells without activation of Na sup + /H sup + exchange
Journal Article
·
· Experimental Cell Research; (USA)
- Univ. of Uppsala (Sweden)
The effect of the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) on cytoplasmic pH (pH{sub i}) and H{sup +} extrusion was studied in the human monoblastic cell line U-937. About 2 min after addition of TPA, pH{sub i} started to increase and reached a steady state 10-15 min later. The resulting alkalinization corresponded to 0.03 and 0.09 pH units at 10{sup {minus}10} and 10{sup {minus}7} M TPA, respectively. The TPA-induced increase in pH{sub i} was independent of the presence of extracellular Na{sup +}. Moreover, TPA did not affect the H{sup +} extrusion from the U-937 cells. Together these observations indicate the presence of a novel mechanism for TPA-induced cytoplasmic alkalinization. This mechanism is independent of Na{sup +}/H{sup +} exchange across the plasma membrane, but may involve organelle sequestration of H{sup +}.
- OSTI ID:
- 6794476
- Journal Information:
- Experimental Cell Research; (USA), Journal Name: Experimental Cell Research; (USA) Vol. 171:1; ISSN ECREA; ISSN 0014-4827
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ANIMAL CELLS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENS
CATIONS
CELL PROLIFERATION
CHARGED PARTICLES
CONNECTIVE TISSUE CELLS
ELEMENTARY PARTICLES
ENZYMES
ESTERS
FERMIONS
HADRONS
IONS
LEUKOCYTES
MACROPHAGES
MATERIALS
MEMBRANE TRANSPORT
MONOCYTES
NUCLEONS
ORGANIC COMPOUNDS
PH VALUE
PHAGOCYTES
PHORBOL ESTERS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PROMOTERS
PROTONS
SODIUM COMPOUNDS
SOMATIC CELLS
TRANSFERASES
TUMOR CELLS
TUMOR PROMOTERS
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ANIMAL CELLS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENS
CATIONS
CELL PROLIFERATION
CHARGED PARTICLES
CONNECTIVE TISSUE CELLS
ELEMENTARY PARTICLES
ENZYMES
ESTERS
FERMIONS
HADRONS
IONS
LEUKOCYTES
MACROPHAGES
MATERIALS
MEMBRANE TRANSPORT
MONOCYTES
NUCLEONS
ORGANIC COMPOUNDS
PH VALUE
PHAGOCYTES
PHORBOL ESTERS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PROMOTERS
PROTONS
SODIUM COMPOUNDS
SOMATIC CELLS
TRANSFERASES
TUMOR CELLS
TUMOR PROMOTERS