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First pass cerebral extraction studies with Tc-99m propylene amine oxime complexes

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6794004
; ; ; ;
Tc-99m propylene amine oxime (Tc-99m-PnAO) is a stable chelate that passively crosses into the crebral cortex. A series of Tc-99m propylene amine oxime derivatives were prepared and studied to determine the effect of lipophilicity on cerebral uptake and retention in rabbit brain.
Research Organization:
Harry S. Truman Memorial Veterans Hospital, Columbia, MO
OSTI ID:
6794004
Report Number(s):
CONF-850611-
Conference Information:
Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKENES
AMINES
ANIMALS
AQUEOUS SOLUTIONS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHELATES
CHEMICAL PREPARATION
CHEMICAL REACTIONS
COMPLEXES
COUNTING TECHNIQUES
DISPERSIONS
DRUGS
EXTRACTION
HOURS LIVING RADIOISOTOPES
HYDROCARBONS
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGANDS
MAMMALS
MIXTURES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIMES
OXYGEN COMPOUNDS
PROPYLENE
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
REDUCTION
REFRACTORY METAL COMPOUNDS
SALINITY
SEPARATION PROCESSES
SOLUTIONS
STABILITY
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
TECHNETATES
TECHNETIUM 99
TECHNETIUM COMPLEXES
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENT COMPOUNDS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES