X-ray induced dysplasia in the developing telencephalic choroid plexus of mice exposed in utero
Journal Article
·
· Teratology; (United States)
Pregnant NMRI-mice were X-irradiated with single doses of 0.95 Gy (100 R) and 1.9 Gy (200 R) on day of gestation (dg) 12. For sampling, anesthetized animals were perfused with buffered glutaraldehyde solution or fixed by immersion in Karnovsky solution. LM, SEM, and TEM studies were carried out on brains prenatally and up to the age of 20 months to follow the radiation effects on the developing lateral choroid plexus. Radiation-induced changes were found using all three methods and at all stages studied. The normally sickle-shaped and stretched choroid plexus is shortened and irregular, and the dome-shaped plexus cells are flattened. Their superficial fine structures, i.e., the microvilli and cilia, are altered. Three stages of severity can be distinguished and the internal hydromicrocephalus increases from stage I to III. Intercellular spaces of the treated plexus epithelium are often dilated, but the tight junctions at the ventricular surface seem to be intact. The interstitium shows large dilations in comparison with the controls. Thus, gross changes and alterations in the fine structure can be induced in the choroid plexus by doses of 0.95 Gy and 1.9 Gy, which persist throughout postnatal life.
- Research Organization:
- Abteilung fuer Nuklearbiologie, Gesellschaft fuer Strahlen, Neuherberg
- OSTI ID:
- 6793862
- Journal Information:
- Teratology; (United States), Journal Name: Teratology; (United States) Vol. 26:1; ISSN TJADA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Thyroxine transport in choroid plexus
Choroid plexus protects cerebrospinal fluid against toxic metals
Ontogeny of specific prolactin binding sites in the rat choroid plexus and their temporal relation to the prolactin short-loop feedback system
Journal Article
·
Thu Oct 15 00:00:00 EDT 1987
· J. Biol. Chem.; (United States)
·
OSTI ID:5727861
Choroid plexus protects cerebrospinal fluid against toxic metals
Journal Article
·
Wed May 01 00:00:00 EDT 1991
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
·
OSTI ID:5752081
Ontogeny of specific prolactin binding sites in the rat choroid plexus and their temporal relation to the prolactin short-loop feedback system
Thesis/Dissertation
·
Mon Dec 31 23:00:00 EST 1984
·
OSTI ID:6067885
Related Subjects
550800 -- Morphology
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MORPHOLOGICAL CHANGES
NERVOUS SYSTEM
ORGANS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
TERATOGENESIS
VERTEBRATES
X RADIATION
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MORPHOLOGICAL CHANGES
NERVOUS SYSTEM
ORGANS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
TERATOGENESIS
VERTEBRATES
X RADIATION