New therapeutic strategies in radiation therapy

Journal Article · Fri Apr 24 04:00:00 EST 1981 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.1981.03310410047030· OSTI ID:6792856

Kinsella, T J ^[1]; Bloomer, W D

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1. National Cancer Inst., Bethesda, MD

Radiation therapy has been an integral part of curative cancer therapy for many decades. The tolerance of normal tissues traversed by radiation and resistant tumor cell populations traditionally have limited the radiocurability of certain tumors, especially with higher clinical stages. However, research in radiobiology and radiation physics is providing ways to increase cure while limiting morbidity. Computer-controlled dynamic treatment, radioprotector drugs, hyperbaric oxygen, carbogen breathing during irradiation, particle irradiation, and hypoxic cell sensitizing drugs are presently undergoing clinical evaluation with some encouraging preliminary results. We review the fundamental concepts underlying these clinical trials and analyze the results.

• OSTI ID: 6792856
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Journal Name: JAMA, J. Am. Med. Assoc.; (United States) Vol. 245:16; ISSN JAMAA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DISEASES
DRUGS
ELEMENTS
IONIZING RADIATIONS
IRRADIATION PROCEDURES
MEDICINE
NEOPLASMS
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NUCLEAR MEDICINE
OXYGEN
PATIENTS
PLANNING
RADIATIONS
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
SIDE EFFECTS
THERAPY