Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effects of supralethal total body irradiation and bone marrow reconstitution upon immunologic memory

Conference · · Transplant. Soc., Int. Cong., Proc.; (United States)
OSTI ID:6792641
; ; ;

The transplantation of bone marrow from prospectively selected genotypically and pedigree DLA-identical donors into supralethally irradiated littermate and nonlittermate recipients within the Copperstown beagle colony has regularly resulted in the establishment of long-term chimerism, with no evidence of graft-versus-host disease in the recipients. It has been demonstrated that irradiated recipients exhibit significant decreases in their ability to muster primary immunological responses during the first months after reconstitution with bone marrow. Beyond the documented capacity of preirradiation blood transfusions to interfere with subsequent engraftment of allogeneic marrow, however, there have been no systematic studies of the possible effects of irradiation and bone marrow transplantation upon immunologic memory. The present study was designed in order to assess this question in greater detail, with particular regard to the effects of irradiation and bone marrow reconstitution upon host sensitization to skin allografts. The results indicate that, within the experimental limitations described, the state of sensitivity produced by first set skin allograft rejection is not affected significantly by supralethal total body irradiation and reconstitution of the recipient with allogeneic bone marrow.

Research Organization:
State Univ. of New York, Stony Brook
OSTI ID:
6792641
Journal Information:
Transplant. Soc., Int. Cong., Proc.; (United States), Journal Name: Transplant. Soc., Int. Cong., Proc.; (United States) Vol. 13:1; ISSN TICPB
Country of Publication:
United States
Language:
English

Similar Records

Immunologic studies of canine bone marrow chimeras. [Gamma radiation]
Journal Article · Tue Jun 01 00:00:00 EDT 1976 · Transplant. Proc.; (United States) · OSTI ID:7346205
Induction of unresponsiveness to major transplantable organs in adult mammals
Journal Article · Mon Oct 01 00:00:00 EDT 1979 · Ann. Surg.; (United States) · OSTI ID:5288624
Induction of allogeneic unresponsiveness by supralethal irradiation and bone marrow reconstitution. [Dogs]
Journal Article · Mon Sep 01 00:00:00 EDT 1980 · Transplant. Proc.; (United States) · OSTI ID:5005521

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
CHIMERAS
DOGS
EVALUATION
EXTERNAL IRRADIATION
GRAFTS
HEMATOPOIETIC SYSTEM
IMMUNITY
IMMUNOSUPPRESSION
IRRADIATION
MAMMALS
MOSAICISM
ORGANS
RADIATION EFFECTS
RADIOINDUCTION
SKIN
SUPRALETHAL IRRADIATION
TISSUES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION