The biological effect of inhomogeneous dose distributions in fractionated radiotherapy

Journal Article · Sun Jul 01 04:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90155-D· OSTI ID:6791460

Yaes, R J ^[1]

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1. Univ. of Kentucky Medical Cener, Lexington (USA)

The linear quadratic (LQ) model is applied to an organ receiving a fractionated course of radiotherapy with an inhomogeneous dose distribution. It is shown that the gradient in the extrapolated response dose (ERD) will be steeper than the gradient in the physical dose. This effect will be greatest for an organ with a small alpha/beta ratio treated with large dose fractions. Clinical implications are discussed with an emphasis on radiation myelitis.

• OSTI ID: 6791460
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (USA) Vol. 19:1; ISSN IOBPD; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
CENTRAL NERVOUS SYSTEM
DOSE-RESPONSE RELATIONSHIPS
FRACTIONATED IRRADIATION
IRRADIATION
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
RADIATION DOSE DISTRIBUTIONS
RADIOLOGY
RADIOTHERAPY
SPINAL CORD
THERAPY