Protection by WR-2721 and WR-151327 against late effects of gamma rays and neutrons

Conference · Mon Jan 01 04:00:00 EST 1990

DOI:https://doi.org/10.1016/0273-1177(92)90115-E· OSTI ID:6789904

Grdina, D J; Carnes, B A; Nagy, B

Two thiophosphoroate compounds WR-2721 and WR-151327 were assessed for their ability to modify the deleterious effects (life shortening and carcinogenesis) of fission-spectrum neutrons or gamma rays on B6CF1 hybrid mice. Male and female mice were irradiated individually at 110 days of age. Radioprotectors were administered intraperitoneally 30 min prior to irradiation. Animals were housed five to a cage; cage locations in the holding rooms were randomized by computer. Animals were checked daily and all deceased animals were necropsied. WR-2721 afforded protection against both neutron- and gamma-ray-induced carcinogenesis and subsequent life shortening. Cumulative survival curves for unirradiated mice of either sex were unaffected by protectors. 28 refs., 6 figs.

• Research Organization: Argonne National Lab., IL (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 6789904
• Report Number(s): CONF-9006220-4; ON: DE90017792
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FERMIONS
FISSION NEUTRONS
GAMMA RADIATION
HADRONS
HAZARDS
HEALTH HAZARDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
NEUTRONS
NUCLEONS
PATHOGENESIS
PHOSPHORUS COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RODENTS
SULFUR COMPOUNDS
SURVIVAL CURVES
VERTEBRATES