Rise of inhaled toluene, ethyl benzene, m-xylene, or mesitylene in rat blood after treatment with ethanol
Toluene, ethyl benzene, m-xylene, and mesitylene (1,3,5-methyl benzene) are widespread as solvents in industries and laboratories or in the manufacture and application of glues, paints, printing inks etc. These aromatics may be absorbed by employees during exposure at the workplace. Alcoholic beverages may be consumed during occupational inhalation or after shift's end at times. Toxicokinetic interactions between the aromatics and ethanol must be assumed because of the common pathway of biotransformation. The blood levels of toluene and m-xylene after inhalation increased significantly in volunteers dosed simultaneously with ethanol. In this view the present experiments in rats should elucidate whether the blood concentrations of inhaled ethyl benzene and mesitylene (both structurally related to toluene and m-xylene) can rise under the influence of ethanol, and whether quantitative differences of this effect due to the structure of these aromatics can occur. From the results informations important for the assessment of occupational health risk are to be expected.
- Research Organization:
- Univ. of Heidelberg, Mannheim, West Germany
- OSTI ID:
- 6787961
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 37:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AROMATICS
BLOOD CHEMISTRY
HEALTH HAZARDS
INHALATION
SYNERGISM
ETHANOL
BENZENE
GAS CHROMATOGRAPHY
HYDROCARBONS
MASS SPECTROSCOPY
PERSONNEL
RATS
TOLUENE
XYLENES
ALCOHOLS
ALKYLATED AROMATICS
ANIMALS
CHROMATOGRAPHY
HAZARDS
HYDROXY COMPOUNDS
INTAKE
MAMMALS
ORGANIC COMPOUNDS
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology