Decomposition of sparked SF/sub 6/ and cytotoxicity of SF/sub 6/ decomposition products

Conference · Wed May 09 04:00:00 EDT 1984

OSTI ID:6782025

Griffin, G D; Sauers, I; Easterly, C E; Ellis, H W; Christophorou, L G

While previously reported that sparked SF/sub 6/ was cytotoxic to mammalian cells, SF/sub 6/ itself was without biological activity. Using quadrupole mass spectrometric analysis of sparked SF/sub 6/, we found the by-products to include SOF/sub 2/, SO/sub 2/F/sub 3/, SF/sub 4/, SOF/sub 4/, SiF/sub 4/, SO/sub 2/, and HF. We investigated the cytotoxicity of the decomposition products toward hamster lung cells using a colony formation assay. SO/sub 2/ and HF were not cytotoxic at any concentration tested. SO/sub 2/F/sub 3/ and SiF/sub 4/, although strongly cytotoxic at higher concentrations than found in sparked SF/sub 6/, were without cytotoxic activity at lower concentrations. SOF/sub 2/ concentrations of 2% were only weakly cytotoxic; 5% concentrations produced approx. 50% and 89% cell death following 1 and 4 h of exposure. SOF/sub 4/ had only weak cytotoxic activity at 0.2% concentration, although there was evidence of strong cytotoxic activity (>80% cell death) following 4 h of exposure to 1% SOF/sub 4/. SF/sub 4/ exhibited no significant cytotoxic activity at 0.5% concentration, although concentrations of 1 and 2% showed definite cytotoxicity, particularly after 4 h of exposure. 17 references, 6 figures, 1 table.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 6782025
• Report Number(s): CONF-8405189-1; ON: DE84012342
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400400 -- Electrochemistry
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CELL CULTURES
CHALCOGENIDES
DATA
ELECTROLYSIS
EXPERIMENTAL DATA
FLUORIDES
FLUORINE COMPOUNDS
HALIDES
HALOGEN COMPOUNDS
HAMSTERS
HYDROFLUORIC ACID
HYDROGEN COMPOUNDS
INFORMATION
INORGANIC ACIDS
LUNGS
LYSIS
MAMMALS
NUMERICAL DATA
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
SILICON COMPOUNDS
SILICON FLUORIDES
SULFUR COMPOUNDS
SULFUR FLUORIDES
SULFUR OXIDES
TOXICITY
VERTEBRATES