Measuring functioning hepatocytes using Tc-99m galactosylneoglycoalbumin (Tc-NGA)

Conference · Sun Jan 01 00:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6780409

Stadalnik, R C; Vera, D R; Quadro, R E; Krohn, K A; Scheibe, P O; O'Grady, L F

Tc-NGA is a synthetic ligand which binds only to hepatic binding protein (HBP), a receptor found only in the liver. It exhibits the properties of high tissue specificity, affinity-dependent uptake, and dose-dependent uptake. Tc-NGA provides an opportunity to study the functioning hepatocyte. The authors evaluated the usefulness of this technique in patients with hepatitis and hepatoma. After intravenous administration of 5 mCi Tc-NGA, dynamic images were acquired for 30 minutes followed by static views. Estimates of HBP concentrations were obtained by kinetic analysis of blood and liver time-activity curves. Kinetic estimates (reduced chi-squares < 3.0) of HBP correlated well with the clinical course and histology. For example, a patient with hepatoma whose calculated receptor population (functioning hepatocytes) was 3.0 +- 0.9 x 10/sup -7/ mole, which is the normal range, is doing well undergoing chemotherapy. Liver biopsy demonstrated normal liver tissue except for the hepatoma. Another patient with hepatoma who had a severely depressed receptor population, 1.2 +- 0.2 x 10/sup -8/ mole, expired one week after the study. Liver biopsy demonstrated practically no normal tissue. Thus, by means of a complementary, receptor radiopharmaceutical and mathematical model, one should be able to quantitatively follow hepatocyte function and predict response to a therapeutic regimen.

• Research Organization: Univ. of California, Davis Medical Center, Sacramento, CA
• OSTI ID: 6780409
• Report Number(s): CONF-840619-
• Journal Information: J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
DIAGNOSTIC USES
LABELLING
HEPATOMAS
DIAGNOSIS
LIVER
LIVER CELLS
RADIOISOTOPE SCANNING
TECHNETIUM 99
AFFINITY
BLOOD
IMAGE PROCESSING
LIGANDS
PATIENTS
QUANTITY RATIO
RECEPTORS
TIME DEPENDENCE
UPTAKE
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
COUNTING TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATERIALS
MEMBRANE PROTEINS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROCESSING
PROTEINS
RADIOISOTOPES
SOMATIC CELLS
TECHNETIUM ISOTOPES
USES
YEARS LIVING RADIOISOTOPES
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