PET measurements of cerebral metabolism corrected for CSF contributions
Thirty-three subjects have been studied with PET and anatomic imaging (proton-NMR and/or CT) in order to determine the effect of cerebral atrophy on calculations of metabolic rates. Subgroups of neurologic disease investigated include stroke, brain tumor, epilepsy, psychosis, and dementia. Anatomic images were digitized through a Vidicon camera and analyzed volumetrically. Relative areas for ventricles, sulci, and brain tissue were calculated. Preliminary analysis suggests that ventricular volumes as determined by NMR and CT are similar, while sulcal volumes are larger on NMR scans. Metabolic rates (18F-FDG) were calculated before and after correction for CSF spaces, with initial focus upon dementia and normal aging. Correction for atrophy led to a greater increase (%) in global metabolic rates in demented individuals (18.2 +- 5.3) compared to elderly controls (8.3 +- 3.0,p < .05). A trend towards significantly lower glucose metabolism in demented subjects before CSF correction was not seen following correction for atrophy. These data suggest that volumetric analysis of NMR images may more accurately reflect the degree of cerebral atrophy, since NMR does not suffer from beam hardening artifact due to bone-parenchyma juxtapositions. Furthermore, appropriate correction for CSF spaces should be employed if current resolution PET scanners are to accurately measure residual brain tissue metabolism in various pathological states.
- Research Organization:
- Hospital of the Univ. of Pennsylvania, Philadelphia, PA
- OSTI ID:
- 6779542
- Report Number(s):
- CONF-840619-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
AGE GROUPS
AGED ADULTS
ALDEHYDES
ANIMAL TISSUES
ATROPHY
BODY
BRAIN
CAMERA TUBES
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELDERLY PEOPLE
EMISSION COMPUTED TOMOGRAPHY
EPILEPSY
GLUCOSE
HEXOSES
HUMAN POPULATIONS
IMAGE PROCESSING
IMAGE TUBES
IMAGES
MENTAL DISORDERS
METABOLISM
MINORITY GROUPS
MONOSACCHARIDES
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NMR IMAGING
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
POPULATIONS
POSITRON COMPUTED TOMOGRAPHY
PROCESSING
SACCHARIDES
TISSUES
TOMOGRAPHY
VIDICONS