Heavy ion beam model for radiobiology
An ad hoc model of energetic heavy ion beams, including secondary and tertiary particles, has been constructed for predicting radiobiological experiments. While the beam model is relatively primitive, it yields depth-dose and depth-radiobiological calculations in good agreement with experiment upstream of the Bragg peak. Beyond the peak the model is somewhat coarse grained and seems to underestimate low-LET fragment production. These defects can be repaired at some cost in computer time. Presently a complete set of depth-dose and radiobiological results (RBE, OER, aerobic and hypoxic survival) is obtained in 4 to 8 min, for a single beam, at a cost of $10. The model can be extended to mixed radiation fields, or to explore the design of ridge filters. These predictions are based on cellular radiosensitivity parameters extracted from track-segment irradiations at about 8 MeV/amu. Their success implies that no new radiobiological results arise from irradiation with beams at 500 MeV/amu.
- Research Organization:
- Univ. of Nebraska, Lincoln
- OSTI ID:
- 6779123
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 83:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
655003* -- Medical Physics-- Dosimetry
AEROBIC CONDITIONS
ANAEROBIC CONDITIONS
ANIMAL CELLS
ANIMALS
ARGON
BEAMS
BIOLOGY
BODY
BRAGG CURVE
CARBON
DATA
DEPTH DOSE DISTRIBUTIONS
DIAGRAMS
ELEMENTS
ENERGY TRANSFER
EXPERIMENTAL DATA
FLUIDS
GASES
HELIUM
INFORMATION
ION BEAMS
KIDNEYS
LET
MAMMALS
MAN
MATHEMATICAL MODELS
MOCKUP
NEON
NONMETALS
NUMERICAL DATA
ORGANS
OXYGEN ENHANCEMENT RATIO
PHANTOMS
PRIMATES
RADIATION DOSE DISTRIBUTIONS
RADIOBIOLOGY
RADIOSENSITIVITY
RARE GASES
RBE
SPATIAL DOSE DISTRIBUTIONS
STRUCTURAL MODELS
SURVIVAL CURVES
VERTEBRATES