Human alpha-fetoprotein: immunosuppressive activity and microheterogeneity

Journal Article · Sat Dec 31 23:00:00 EST 1977 · Immunol. Commun.; (United States)

DOI:https://doi.org/10.3109/08820137809033881· OSTI ID:6777499

Lester, E P; Miller, J B; Yachnin, S

Purified human alpha-fetoprotein (HAFP) from five patients with hepatoma, one with gastric carcinoma, one with an embryonal cell tumor, and from fetal liver has demonstrated immunosuppressive potencies in vitro which vay over three orders of magnitude. A reversible association of HAFP with the cell surface and a predominant effect on T cells are suggested. No evidence of complex formation between HAFP and mitogen has been found. The microheterogeneity of HAFP has been detailed with crossed immunoelectrophoresis and isoelectric focusing in polyacrylamide gels containing 8M urea, and the immunosuppressive potency of HAFP isolated from a given source can be correlated with the proportion of certain HAFP species contained in it.

• Research Organization: Univ. of Chicago, IL
• OSTI ID: 6777499
• Journal Information: Immunol. Commun.; (United States), Journal Name: Immunol. Commun.; (United States) Vol. 7:2; ISSN IMLCA
• Country of Publication: United States
• Language: English

Related Subjects

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550900 -- Pathology
59 BASIC BIOLOGICAL SCIENCES
AMIDES
ANIMAL CELLS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBONIC ACID DERIVATIVES
CELL CULTURES
CELL DIVISION
CHEMISTRY
CONNECTIVE TISSUE CELLS
CYTOLOGY
DIGESTIVE SYSTEM
DISEASES
ELECTROPHORESIS
GLANDS
HELA CELLS
HEPATOMAS
IMMUNOSUPPRESSION
IN VITRO
INHIBITION
LEUKOCYTES
LIVER
LYMPHOCYTES
MAMMALS
MAN
MITOSIS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PROTEINS
SOMATIC CELLS
UREA
VERTEBRATES