Cell population kinetic parameters for acute epidermal reactions in man

Journal Article · Sat Nov 01 00:00:00 EST 1986 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576819· OSTI ID:6776294

Cohen, L

Cell population kinetic parameters for acute reactions in squamous epithelium were estimated using available data on skin tolerance doses. Roughly equivalent doses for kilovoltage radiation delivered in equal daily fractions, as reported by F. Ellis (Br. J. Radiol. 15, 348-350 (1942)) and by R. Paterson (The Treatment of Malignant Disease by Radium and X-Rays. Edward Arnold, London, 1948), were combined with data for nonstandard fractionation at longer intervals of 1 or 2 weeks. By analyzing the combined data set, well-determined parameters could be derived. The data show that repopulation, with a potential cell doubling time of about 7 days, must occur in irradiated human skin, though this may possibly be limited to no more than seven doublings. The parameters derived are distinctly different from those associated with late-reacting dose-limiting tissues. The main difference is the steeper initial slope of the computed survival curve, that is a larger J parameter (multitarget model) or a larger alpha component (linear-quadratic model).

• Research Organization: Michael Reese Medical Center, Chicago, IL
• OSTI ID: 6776294
• Journal Information: Radiat. Res.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EPITHELIUM
BIOLOGICAL RADIATION EFFECTS
CELL DIVISION
FRACTIONATED IRRADIATION
RADIATION DOSES
SKIN
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
DOSES
IRRADIATION
ORGANS
RADIATION EFFECTS
TISSUES
560151* - Radiation Effects on Animals- Man