Proton MR spectroscopy in herpes simplex encephalitis: Assessment of neuronal loss

Journal Article · Tue May 01 00:00:00 EDT 1990 · Journal of Computer Assisted Tomography; (USA)

DOI:https://doi.org/10.1097/00004728-199005000-00024· OSTI ID:6774379

Menon, D K; Sargentoni, J; Peden, C J; Bell, J D; Cox, I J; Coutts, G A; Baudouin, C; Newman, C G ^[1]

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1. NMR Unit, Hammersmith Hospital, London (England)

We present here the case of an 11-year-old boy with herpes simplex encephalitis diagnosed on the basis of clinical features, serology, and response to acyclovir, who relapsed after 3 weeks of therapy. In vivo proton magnetic resonance spectroscopy (1H MRS) of the brain, at 8 and 16 weeks after the onset of symptoms, showed abnormalities, most prominently a reduction in the N-acetylaspartate/choline ratio. The role of 1H MRS in assessing disease activity is discussed.

• OSTI ID: 6774379
• Journal Information: Journal of Computer Assisted Tomography; (USA), Vol. 14:3; ISSN 0363-8715
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NMR IMAGING
ENCEPHALITIS
DIAGNOSIS
ASPARTIC ACID
CHILDREN
CHOLINE
HERPES SIMPLEX
MAN
NUCLEAR MAGNETIC RESONANCE
PHOSPHOCREATINE
PROTONS
AGE GROUPS
ALCOHOLS
AMINES
AMINO ACIDS
AMMONIUM COMPOUNDS
ANIMALS
BARYONS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELEMENTARY PARTICLES
FERMIONS
HADRONS
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
LIPOTROPIC FACTORS
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEONS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PRIMATES
QUATERNARY COMPOUNDS
RESONANCE
SKIN DISEASES
VERTEBRATES
VIRAL DISEASES
550600* - Medicine