Response of the RIF-1 tumor in vitro and in C3H/Km mice to x-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages
Journal Article
·
· J. Natl. Cancer Inst.; (United States)
OSTI ID:6773992
- Stanford Univ., School of Medicine, CA
The radiation response of logarithmic growth phase and fed plateau phase RIF-1 cells in vitro was found to be characterized by D/sub 0/ values of 110 and 133 rads and extrapolation numbs of 36 and 28, respectively. The response of the tumor in vivo to X-irradiation in nonanesthetized mice showed a dependence on the tumor implantation site. In the leg muscle, the response indicated that most cells were at an intermediate level of oxygenation, whereas in the subcutaneous tissue of the flank, the response of the tumor indicated that it had a small fraction of hypoxic cells of maximum radioresistance. Misonidazole radiosensitized the leg-implanted tumor as measured both by cell survival and regrowth delay. The tumor was relatively insensitive to a single dose of 1,3-bis(2-chloroethyl)-1-nitrosourea, sensitive to a single dose of cis-platinum, and highly sensitive to a single dose of cyclophosphamide.
- OSTI ID:
- 6773992
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 64:3; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300* -- Cytology
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIMITOTIC DRUGS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
GROWTH
IN VITRO
INHIBITION
INJECTION
INTAKE
INTRAMUSCULAR INJECTION
IONIZING RADIATIONS
MACROPHAGES
MAMMALS
MICE
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHAGOCYTES
PLATINUM COMPOUNDS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SUBCUTANEOUS INJECTION
SURVIVAL CURVES
THERAPY
TRANSITION ELEMENT COMPOUNDS
TUMOR CELLS
VERTEBRATES
X RADIATION
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIMITOTIC DRUGS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
ENDOXAN
GROWTH
IN VITRO
INHIBITION
INJECTION
INTAKE
INTRAMUSCULAR INJECTION
IONIZING RADIATIONS
MACROPHAGES
MAMMALS
MICE
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHAGOCYTES
PLATINUM COMPOUNDS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SUBCUTANEOUS INJECTION
SURVIVAL CURVES
THERAPY
TRANSITION ELEMENT COMPOUNDS
TUMOR CELLS
VERTEBRATES
X RADIATION