Gonadal function after 12-Gy testicular irradiation in childhood acute lymphoblastic leukemia

Journal Article · Sun Dec 31 23:00:00 EST 1989 · Medical and Pediatric Oncology; (USA)

DOI:https://doi.org/10.1002/mpo.2950180304· OSTI ID:6772239

Castillo, L A; Craft, A W; Kernahan, J; Evans, R G; Aynsley-Green, A ^[1]

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1. Royal Victoria Infirmary, Newcastle upon Tyne (England)

Gonadal function was assessed in 15 boys with acute lymphoblastic leukemia (ALL) who had received testicular irradiation. The dose to the testes was 12 Gy in 12, 15 Gy in 1, and 24 Gy in 2 cases. All of those who had received 12 or 15 Gy had normal Leydig cell function, although high levels of gonadotropins suggest subclinical Leydig cell damage. The 2 who had 24 Gy had Leydig cell failure. All who were old enough to produce a semen specimen were azoospermic.

• OSTI ID: 6772239
• Journal Information: Medical and Pediatric Oncology; (USA), Journal Name: Medical and Pediatric Oncology; (USA) Vol. 18:3; ISSN 0098-1532; ISSN MPOND
• Country of Publication: United States
• Language: English

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ANDROSTANES
BIOASSAY
BIOLOGICAL EFFECTS
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KETONES
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MALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
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ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
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RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
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