Relationship between fractionation and total dose for x ray induced brain damage. [Rats]

Journal Article · Sun Mar 01 04:00:00 EST 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90114-0· OSTI ID:6769851

Hornsey, S; Morris, C C; Myers, R

An isoeffect curve for x ray induced brain damage in the rat has been obtained by comparing the effects of fractionation of dose into 8, 15 or 30 equal fractions given in the same overall treatment time of 6 weeks. The slope of the isoeffect curve is 0.37. This data on the brain is compared with other published data for radiation damage to the rat spinal cord and a composite isoeffect curve for damage to the central nervous system (CNS) is shown. From this we suggest a modified formula for the CNS that is the agreement with that suggested by van der Kogel for the spinal cord, and is more compatible with present clinical experience than the normal Ellis formula.

• Research Organization: Hammersmith Hospital, London
• OSTI ID: 6769851
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CORRELATIONS
DOSES
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
IONIZING RADIATIONS
IRRADIATION
ISODOSE CURVES
MAMMALS
NECROSIS
NERVOUS SYSTEM
ORGANS
PATHOLOGICAL CHANGES
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RODENTS
SPINAL CORD
VERTEBRATES
X RADIATION