Effect of target-gas purity on the chemical form of F-18 during /sup 18/F-F/sub 2/ production using the neon/fluorine target

Journal Article · Fri Aug 01 04:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:6765436

Bida, G T; Ehrenkaufer, R L; Wolf, A P; Fowler, J S; MacGregor, R R; Ruth, T J

Irradiation of gas mixtures of F/sub 2//Ne (/sup 20/Ne ..-->.. /sup 18/F) which contained percent levels (> 0.1%) of N/sub 2/, CO/sub 2/, or CF/sub 4/ resulted in the production of unacceptable levels of F-18-labeled NF/sub 3/ and CF/sub 4/ at the expense of /sup 18/F-F/sub 2/. Analytical gas chromatographic methods have been devised to determine contaminant levels in the target gas as well as in the products arising from them. Commercial mixtures of 1% F/sub 2//Ne, pure F/sub 2/, and neon have been analyzed for contaminants (N/sub 2/, O/sub 2/, CO, CO/sub 2/, and CF/sub 4/) and found to vary widely in the levels of these impurities from batch to batch. The N/sub 2/ levels in the 1% F/sub 2//Ne mixtures varied from 0.039 to 0.49%, and the CO/sub 2/ levels from 0.028 to 0.13%. No detectable impurities were found in the neon (Research Purity), but F/sub 2/ was found to contain approx. 11% CF/sub 4/. Reproducibly high yields of /sup 18/F-F/sub 2/ are obtained if the levels of N/sub 2/, CO/sub 2/, and CF/sub 4/ in the final target gas mixture are < 0.01% and carrier F/sub 2/ is approx. 0.1%. Hydrocarbons and CO were not detected in our gas mixtures, but would also be expected to decrease yields of /sup 18/F-F/sub 2/.

• Research Organization: Brookhaven National Lab., Upton, NY
• OSTI ID: 6765436
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry &amp; Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON FLUORIDES
CARBON OXIDES
CHALCOGENIDES
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
CHROMATOGRAPHY
CONTAMINATION
DIAGNOSTIC USES
DRUGS
ELEMENTS
FLUORIDES
FLUORINE 18
FLUORINE COMPOUNDS
FLUORINE ISOTOPES
GAS CHROMATOGRAPHY
HALIDES
HALOGEN COMPOUNDS
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MATERIALS
NITROGEN
NONMETALS
NUCLEI
ODD-ODD NUCLEI
OXIDES
OXYGEN COMPOUNDS
QUANTITATIVE CHEMICAL ANALYSIS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SYNTHESIS
USES
YIELDS