Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

The contribution of late-generated neurons to the callosal projection in rat: a study with prenatal x-irradiation

Journal Article · · J. Comp. Neurol.; (United States)
;

Studies utilizing horseradish peroxidase tracing methods have suggested that there are species differences in the relative contribution of the different neocortical layers to the callosal projection. The present investigation utilized x-irradiation at different gestational ages to eliminate the late-generated neurons in the rat neocortex. The caudorostral gradient of reduction in the neuronal population of the supragranular layers is closely correlated with the gradient of reduction in the size of the corpus callosum. Furthermore, the callosal projection is absent in anteroposterior cortical segments in which the development of the supragranular layers was prevented without a reduction of the number of neurons in the infragranular layers of the neocortex. These results indicate that late-generated neurons residing primarily in the supragranular layers are essential for the formation of the corpus callosum.

Research Organization:
Laboratory of Developmental Neurobiology, Department of Biological Sciences, Purdue University, West Lafayette, Indiana
OSTI ID:
6764218
Journal Information:
J. Comp. Neurol.; (United States), Journal Name: J. Comp. Neurol.; (United States) Vol. 209:2; ISSN JCNEA
Country of Publication:
United States
Language:
English

Similar Records

Effects of prenatal irradiation on the development of cerebral cortex and corpus callosum of the mouse
Journal Article · Thu Oct 08 00:00:00 EDT 1987 · J. Comp. Neurol.; (United States) · OSTI ID:5602400
The afferent and efferent callosal connections of retinotopically defined areas in cat cortex
Journal Article · Sun Aug 01 00:00:00 EDT 1982 · J. Neurosci.; (United States) · OSTI ID:6578903
D-(/sup 3/H)aspartate retrograde labelling of callosal and association neurons of somatosensory areas I and II of cats
Journal Article · Tue Sep 08 00:00:00 EDT 1987 · J. Comp. Neurol.; (United States) · OSTI ID:5784324

Related Subjects

550800 -- Morphology
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CELL DIFFERENTIATION
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
DELAYED RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MORPHOLOGY
NERVE CELLS
NERVOUS SYSTEM
ORGANS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SOMATIC CELLS
VERTEBRATES
X RADIATION