Molecular genetics in affective illness

Journal Article · Fri Jan 01 04:00:00 EST 1993 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(93)90214-N· OSTI ID:6762106

Mendlewicz, J; Sevy, S; Mendelbaum, K ^[1]

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1. Erasme Univ. Hospital, Brussels (Belgium)

Genetic transmission in manic depressive illness (MDI) has been explored in twins, adoption, association, and linkage studies. The X-linked transmission hypothesis has been tested by using several markers on chromosome X: Xg blood group, color blindness, glucose-6-phosphate dehydrogenase (G6PD), factor IX (hemophilia B), and DNA probes such as DXS15, DXS52, F8C, ST14. The hypothesis of autosomal transmission has been tested by association studies with the O blood group located on chromosome 9, as well as linkage studies on chromosome 6 with the Human Leucocyte Antigens (HLA) haplotypes and on Chromosome 11 with DNA markers for the following genes: D2 dopamine receptor, tyrosinase, C-Harvey-Ras-A (HRAS) oncogene, insuline (ins), and tyrosine hydroxylase (TH). Although linkage studies support the hypothesis of a major locus for the transmission of MDI in the Xq27-28 region, several factors are limiting the results, and are discussed in the present review. 105 refs., 1 fig., 2 tabs.

• OSTI ID: 6762106
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 52:3; ISSN 0024-3205; ISSN LIFSAK
• Country of Publication: United States
• Language: English

Related Subjects

550400* -- Genetics
59 BASIC BIOLOGICAL SCIENCES
AMINES
AMINO ACIDS
ANTIGENS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BIOLOGY
BLOOD
BLOOD CELLS
BLOOD GROUPS
BODY FLUIDS
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHROMOSOMES
DATA
DOPAMINE
DRUGS
ENZYMES
EXPERIMENTAL DATA
GENES
GENETIC MAPPING
GENETICS
HETEROCHROMOSOMES
HUMAN CHROMOSOMES
HUMAN X CHROMOSOME
HYDROXY ACIDS
HYDROXY COMPOUNDS
HYDROXYLASES
INFORMATION
LEUKOCYTES
MAPPING
MATERIALS
MEMBRANE PROTEINS
MENTAL DISORDERS
NEUROREGULATORS
NUMERICAL DATA
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PHENOLS
POLYPHENOLS
PROTEINS
RECEPTORS
SYMPATHOMIMETICS
TYROSINASE
TYROSINE
X CHROMOSOME