Differential effects on RNA translation by a KCl extract of reticulocyte ribosomes: characteristics of an inhibitory fraction
Journal Article
·
· Biochem. Biophys. Res. Commun.; (United States)
A KCl extract of rabbit reticulocyte ribosomes has been demonstrated to markedly stimulate the translation of various messenger RNAs in cell-free system from Krebs II ascites tumor cells. In contrast, the translation of encephalomyocarditis viral RNA is strongly inhibited by the same extract. Fractionation of the KCl extract allows the separation of these inhibitory and stimulatory activities. The inhibitory activity has been shown to be the consequence of an unusual endonuclease, associated with ribosomes, that produces approximately 4 S products from the degradation of globin mRNA and viral RNA.
- Research Organization:
- Oak Ridge National Lab., TN
- OSTI ID:
- 6760847
- Journal Information:
- Biochem. Biophys. Res. Commun.; (United States), Journal Name: Biochem. Biophys. Res. Commun.; (United States) Vol. 90:3; ISSN BBRCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200* -- Biochemistry
550300 -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
ASCITES TUMOR CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CHLORIDES
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
ENZYMES
ERYTHROCYTES
ESTERASES
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
IN VITRO
INHIBITION
MAMMALS
MATERIALS
MESSENGER-RNA
MICROORGANISMS
NUCLEASES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
PARASITES
PHOSPHODIESTERASES
POTASSIUM CHLORIDES
POTASSIUM COMPOUNDS
RABBITS
RETICULOCYTES
RIBOSOMES
RNA
SIDE EFFECTS
SYNTHESIS
TUMOR CELLS
VERTEBRATES
VIRUSES
550300 -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ALKALI METAL COMPOUNDS
ANIMAL CELLS
ANIMALS
ASCITES TUMOR CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CHLORIDES
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
ENZYMES
ERYTHROCYTES
ESTERASES
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
IN VITRO
INHIBITION
MAMMALS
MATERIALS
MESSENGER-RNA
MICROORGANISMS
NUCLEASES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
PARASITES
PHOSPHODIESTERASES
POTASSIUM CHLORIDES
POTASSIUM COMPOUNDS
RABBITS
RETICULOCYTES
RIBOSOMES
RNA
SIDE EFFECTS
SYNTHESIS
TUMOR CELLS
VERTEBRATES
VIRUSES