Blood nerve barrier in rat and cellular mechanisms of lead-induced segmental demyelination

Journal Article · Sat Nov 01 04:00:00 EST 1980 · J. Neuropathol. Exp. Neurol.; (United States)

DOI:https://doi.org/10.1097/00005072-198011000-00009· OSTI ID:6758899

Dyck, P J; Windebank, A J; Low, P A; Baumann, W J

Feeding of lead carbonate to rats causes widespread and reproducible segmental de- and remyelination of myelinated fibers (MFs) of peripheral nerve. Such segmental demyelination might be explained by increased permeability of endoneurial capillaries to serum containing protein-bound lead. The perineurium of control and lead nerves was impermeable to fluorescein-labeled bovine albumin (FBA) and to horseradish peroxidase (HRP). Epineurial capillaries in both conditions allowed HRP to pass freely between and, to a lesser extent, through endothelial cells. Contrary to expectation, flooding of the endoneurium with HRP was seen in only 1 of 36 tissue blocks of lead nerves from rats fed 4% lead carbonate for 7 1/2 and 12 weeks. Abundant HRP reaction product was seen in the epineurium in more than half of these tissue blocks. HRP was not generally found in endoneurial fluid, even in lead nerves with marked edema and widespread segmental de- and remyelination. These findings are against a massive breakdown of the blood nerve barrier. These studies suggest that there may be an increased transfer of HRP through endoneurial cells in lead neuropathy.

• Research Organization: Mayo Foundation, Rochester, MN
• OSTI ID: 6758899
• Journal Information: J. Neuropathol. Exp. Neurol.; (United States), Journal Name: J. Neuropathol. Exp. Neurol.; (United States) Vol. 39:6; ISSN JNENA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CAPILLARIES
CARBON COMPOUNDS
CARBONATES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CONNECTIVE TISSUE CELLS
EDEMA
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LEAD CARBONATES
LEAD COMPOUNDS
LIPIDS
LIPOPROTEINS
MACROPHAGES
MAMMALS
MEMBRANE TRANSPORT
MYELIN
NERVES
NERVOUS SYSTEM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PEROXIDASES
PHAGOCYTES
PORPHYRINS
PROTEINS
RATS
RODENTS
SIDE EFFECTS
SOMATIC CELLS
SYMPTOMS
VERTEBRATES