Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter
Journal Article
·
· Genomics; (United States)
- Univ. of California, San Diego, CA (United States)
- Univ. of California, Irvine, CA (United States)
- Salk Institute for Biological Studies, San Diego, CA (United States)
Degenerate DNA oligomers coding for highly conserved regions of the voltage-gated calcium channel were synthesized for the polymerase chain reaction (PCR) using DNA from a human brain cDNA library as template. PCR amplified a 640-bp DNA fragment from the human brain cDNA library. Sequencing revealed that this fragment encodes part of a protein highly homologous to a subtype of the dihydropyridine-sensitive calcium channel cloned from rabbit heart and rat brain. Southern analysis of panels of somatic cell hybrids mapped the 640-bp fragment, CACNL1A1, to human chromosome 12p13-pter. 17 refs., 2 figs.
- OSTI ID:
- 6758364
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 14:4; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
Similar Records
Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors
Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog CBFA3, to chromosome 1p35-pter
Targeted gene walking by low stringency polymerase chain reaction: Assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31
Journal Article
·
Fri Feb 14 23:00:00 EST 1992
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:5445315
Identification of a new murine runt domain-containing gene, Cbfa3, and localization of the human homolog CBFA3, to chromosome 1p35-pter
Journal Article
·
Mon Apr 10 00:00:00 EDT 1995
· Genomics
·
OSTI ID:209948
Targeted gene walking by low stringency polymerase chain reaction: Assignment of a putative human brain sodium channel gene (SCN3A) to chromosome 2q24-31
Journal Article
·
Tue Apr 12 00:00:00 EDT 1994
· Proceedings of the National Academy of Sciences of the United States of America
·
OSTI ID:256467