Evaluation of log K{sub ow} and tissue lipid content as predictors of chemical partitioning to fish tissues
Journal Article
·
· Environmental Toxicology and Chemistry
- AScI Corp., Duluth, MN (United States)
- Environmental Protection Agency, Duluth, MN (United States). Mid-Continent Ecology Div.
In vitro equilibrium chemical partition coefficients were determined for six chemicals in selected tissues from four species of fish. Log-transformed values were then regressed in stepwise fashion against chemical log octanol/water partition coefficient (K{sub ow}) and the log of tissue lipid content to derive a series of linear one- and two-variable models. Equations derived for fat indicate that n-octanol is a good surrogate for nonpolar lipid in the range of chemical log K{sub ow} tested (1.46 < log K{sub ow} < 4.04). These equations also support the conclusion that previously developed K{sub ow}-bioconcentration factor relationships are largely a reflection of chemical accumulation in fat. Fitted slope and intercept terms for lean tissues differed from those expected from chemical partitioning to lipid only and were instead consistent with the suggestion that partitioning to nonlipid-nonwater cellular constituents contributes substantially to chemical accumulation. A general equation is presented for prediction of tissue/water and blood/water partitioning from chemical log K{sub ow} and tissue (or blood) lipid content. It is suggested, however, that tissue- and blood-specific equations be used to estimate the tissue/blood partitioning relationships needed for kinetic modeling efforts.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 675393
- Journal Information:
- Environmental Toxicology and Chemistry, Journal Name: Environmental Toxicology and Chemistry Journal Issue: 8 Vol. 17; ISSN 0730-7268; ISSN ETOCDK
- Country of Publication:
- United States
- Language:
- English
Similar Records
Bioconcentration of chlorinated aromatic hydrocarbons in aquatic macrophytes
Relationship between the lipid content of fish and their bioconcentration potential of 1,2,4-trichlorobenzene
Long-term bioconcentration kinetics of hydrophobic chemicals in Selenastrum capricornutum and Microcystis aeruginosa
Journal Article
·
Wed May 01 00:00:00 EDT 1991
· Environmental Science and Technology; (United States)
·
OSTI ID:5000166
Relationship between the lipid content of fish and their bioconcentration potential of 1,2,4-trichlorobenzene
Journal Article
·
Mon Dec 31 23:00:00 EST 1984
· Chemosphere; (United States)
·
OSTI ID:5115573
Long-term bioconcentration kinetics of hydrophobic chemicals in Selenastrum capricornutum and Microcystis aeruginosa
Journal Article
·
Tue Jun 01 00:00:00 EDT 1999
· Environmental Toxicology and Chemistry
·
OSTI ID:6333930