Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine
The transport of pantothenate by the rat small intestine occurs by simple diffusion. There was no significant difference in the rate of pantothenate absorption in the upper, middle or lower sections of the intestine. Coenzyme A was hydrolyzed to pantetheine and pantothenate in the intestinal lumen via the following series of reactions: coenzyme A leads to phosphopantetheine leads to pantetheine leads to pantothenate. Intestinal tissue, which contains high levels of pantetheinase, quickly degrades pantetheine to pantothenate, which is then transported to the blood and thence to other tissues. Tissue distribution patterns of 14C 5 hours after intraluminal administration of 14C-labeled coenzyme A or (14C)pantothenate were similar; approximately 40% of the 14C was present in muscle and 10% in liver.
- OSTI ID:
- 6748713
- Journal Information:
- J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 113:10; ISSN JONUA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
AMINO ACIDS
ANIMALS
BIOCHEMICAL REACTION KINETICS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
COENZYMES
DECOMPOSITION
DIGESTIVE SYSTEM
ENZYME ACTIVITY
GASTROINTESTINAL TRACT
HYDROLYSIS
HYDROXY ACIDS
INTESTINAL ABSORPTION
INTESTINES
KINETICS
LABELLED COMPOUNDS
LYSIS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PANTOTHENIC ACID
RATS
REACTION KINETICS
RODENTS
SMALL INTESTINE
SOLVOLYSIS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS