Computer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminopolycarboxylic acids

Journal Article · Thu Mar 01 00:00:00 EST 1984 · J. Inorg. Biochem.; (United States)

DOI:https://doi.org/10.1016/0162-0134(84)85019-9· OSTI ID:6748458

Duffield, J R; May, P M; Williams, D R

An investigation by computer simulation into the nature of Pu(IV) binding to low-molecular ligands in human blood plasma is described. Particular consideration is given to the interactions of various chelating agents which have been or might be used for treating plutonium intoxication. Formation constants of EDTA and DTPA with Cu(II), Mg(II), Mn(II), Zn(II), and Cd(II) have been measured under biologic conditions of temperature and background electrolyte. The relative ability of these and other chelating agents to cause excretion of plutonium and the concomitant loss of certain essential trace metals has thus been assessed.

• Research Organization: University of Wales Institute of Science and Technology, UK
• OSTI ID: 6748458
• Journal Information: J. Inorg. Biochem.; (United States), Vol. 20:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CLEARANCE
COMPUTERIZED SIMULATION
PLUTONIUM
BLOOD PLASMA
CHELATING AGENTS
DTPA
EDTA
ACTINIDES
AMINO ACIDS
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
DRUGS
ELEMENTS
MATERIALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
SIMULATION
TRANSURANIUM ELEMENTS
560170* - Radiation Effects- Nuclide Kinetics & Toxicology- (-1987)