Bioavailability of cadmium and its human consequence

Technical Report · Sun Jan 01 04:00:00 EST 1984

OSTI ID:6748022

Revis, N W

Cadmium intake for the average adult in the USA from water, air and food is approximately 43 ..mu..g/day. This value does not include intake from cigarette smoking or industrial exposure. Intake from these sources would add significantly the total Cd body burden because, Cd absorption via the respiratory track is approximately 10 times the value observed for the gastrointestinal tract. Renal tubular damage is the only human disease in which a dose-response has been established for Cd intake. For renal tubular damage an intake of 200 to 440 ..mu..g/day for 50 years would be necessary to induce this disease in 50% of the exposed population. Thus a safety margin of 10 exists between present intake levels and the amount required to induce renal tubular damage. If animal studies, which show the induction of hypertension following the long-term exposure to drinking water containing 100 ppB Cd, were related to present human intake values of 43 ..mu..g/day the safety margin level would be considerably lower than 10. In contrast, to relate the data from animal studies on cadmium-induced tumors to present human intake values suggest a safety margin greater than 10. 59 references, 4 tables.

• Research Organization: Oak Ridge Research Inst., TN (USA). Research and Development Dept.
• DOE Contract Number: AC05-82ER60094
• OSTI ID: 6748022
• Report Number(s): DOE/ER/60094-T2; ON: DE84014378
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AEROSOLS
BODY
CADMIUM
COLLOIDS
DATA
DATA COMPILATION
DIET
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
HUMAN POPULATIONS
INFORMATION
INTESTINAL ABSORPTION
KIDNEYS
METALS
NUMERICAL DATA
ORGANS
POPULATIONS
RESIDUES
SMOKES
SOLS
TOBACCO SMOKES
TOXICITY
UPTAKE