Carcinogenicity and epidemiological profile analysis of vinyl chloride and polyvinyl chloride

Journal Article · Thu Mar 01 04:00:00 EST 1984 · Regul. Toxicol. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0273-2300(84)90003-5· OSTI ID:6747990

Kalmaz, E E; Kalmaz, G D

The carcinogenicity of vinyl chloride and polyvinyl chloride (VC/PVC) is reviewed with specific attention to the gaps in knowledge for risk estimation and epidemiological presentation of the available data. Although experimental studies have demonstrated the carcinogenicity and mutagenicity of VC/PVC in general, the epidemiologic studies available for review do not include an assessment of carcinogenic risk among humans exposed to these chemicals. This conclusion is based on the observation that the majority of cohort studies reviewed lacked sufficient statistical power because of small sample sizes. Further, in epidemiological studies, individuals were not followed over an adequate period of time during which cancer could become clinically manifest.

• Research Organization: Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston
• OSTI ID: 6747990
• Journal Information: Regul. Toxicol. Pharmacol.; (United States), Journal Name: Regul. Toxicol. Pharmacol.; (United States) Vol. 4:1; ISSN RTOPD
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOGENESIS
CHLORINATED ALIPHATIC HYDROCARBONS
EPIDEMIOLOGY
EVALUATION
HALOGENATED ALIPHATIC HYDROCARBONS
HUMAN POPULATIONS
MUTAGENESIS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC POLYMERS
PATHOGENESIS
POLYMERS
POLYVINYLS
POPULATIONS
PVC
RISK ASSESSMENT
TOXICITY
VINYL CHLORIDE