Cerebrovascular effects of intraarterial CO/sub 2/ in quantities required for diagnostic imaging. [Rats]
The recent development of digital subtraction angiography (DSA) has renewed interest in the use of gasses, especially carbon dioxide, as contrast agents. Both early physiologic studies and recent clinical reports suggest that arterial CO/sub 2/-DSA is a safe and useful diagnostic tool in the examination of extremity circulation. The present study examined the neurologic sequelae, pathologic changes, and effects on the blood-brain barrier to intravenous Evans-Blue and horseradish peroxidase of intracarotid CO/sub 2/, in albino rats. As with other forms of cerebral gas embolization, CO/sub 2/produced multifocal ischemic infarctions and disrupted the blood-brain barrier to macromolecular tracers. The site of the barrier lesion is the endothelial cell membrane, although the precise mechanisms of damage remain unknown.
- Research Organization:
- Univ. of Florida Medical Center, Gainesville
- OSTI ID:
- 6743624
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 151:2; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BLOOD CIRCULATION
BLOOD VESSELS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHALCOGENIDES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON MICROSCOPY
ISCHEMIA
MAMMALS
MEDICINE
MICROSCOPY
MORPHOLOGICAL CHANGES
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOLOGY
RATS
RODENTS
ULTRASTRUCTURAL CHANGES
VASCULAR DISEASES
VERTEBRATES