Prolongation of rat islet allograft survival by direct ultraviolet irradiation of the graft
Journal Article
·
· Science (Washington, D.C.); (United States)
Ultraviolet irradiation of rat dendritic cells completely abrogated their allostimulatory capacity in a mixed lymphocyte reaction. Rat islets of Langerhans similarly irradiated remained hormonally functional when transplanted into syngeneic diabetic rats. Allogeneic transplantation across a major histocompatibility barrier of islets initially treated in vitro with ultraviolet irradiation resulted in prolonged allograft survival without the use of any immunosuppressive agents.
- Research Organization:
- Harlem Hospital Center, New York, NY
- OSTI ID:
- 6743132
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 223:4636; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
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560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
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ULTRAVIOLET RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
GLANDS
GRAFTS
IMMUNOSUPPRESSION
LEUKOCYTES
LYMPHOCYTES
MATERIALS
ORGANS
PANCREAS
RADIATIONS
SOMATIC CELLS
SURVIVAL TIME
TRANSPLANTS
ULTRAVIOLET RADIATION