Maximum cell productivity by repeated fed-batch culture for constant yield case
Optimal operation of repeatedly fed-batch fermentation was determined by the continuous maximum principle for the constant yield case. The objective of maximum cell productivity for a fixed final cell concentration was achieved by finding the substrate feeding policy that minimized the processing time. Analytical criteria for the optimal filling policy show that an exponential policy is optimum when the specific growth rate has a maximum, and also that operation in the simple repeated batch model is optimum when the specific growth rate is optimum when the specific growth rate is monotonic increasing. Comparisons between optimal repeated fed-batch culture and other modes of operation were made for the case of substrate-inhibited growth. Cell productivity by repeated fed-batch exceeds both repeated batch and continuous operation for the case of low residual substrate concentration.
- Research Organization:
- School of Chemical Engineering, Purdue Univ, West Lafayette, Indiana 47907
- OSTI ID:
- 6742322
- Journal Information:
- Biotechnol. Bioeng.; (United States), Journal Name: Biotechnol. Bioeng.; (United States) Vol. 23:2; ISSN BIBIA
- Country of Publication:
- United States
- Language:
- English
Similar Records
A note on the optimality criteria for maximum biomass production in a fed-batch fermentor
Optimal operation of a repeated fed-batch bioreactor for biomass production from a methanol-utilizing bacterium
Related Subjects
140504* -- Solar Energy Conversion-- Biomass Production & Conversion-- (-1989)
ALDEHYDES
BATCH CULTURE
BIOCONVERSION
CARBOHYDRATES
CONTINUOUS CULTURE
FERMENTATION
FUNGI
GLUCOSE
GROWTH
HEXOSES
MONOSACCHARIDES
ORGANIC COMPOUNDS
PENICILLIUM
PLANTS
PRODUCTIVITY
SACCHARIDES
SEMIBATCH CULTURE
SUBSTRATES